cas 107761-42-2 Amyloid β-Peptide (1-42) (human) β-Amyloid-42 β-amyloid polypeptide 42

Product Description

Description

CAS number 107761-42-2 corresponds to the compound Amyloid β-Peptide (1-42) (human). It is a peptide fragment derived from the amyloid precursor protein (APP) and is associated with the formation of amyloid plaques in the brains of individuals with Alzheimer's disease.

The amyloid β-peptide (Aβ) is a protein fragment consisting of amino acids 1 to 42 of the full-length amyloid β-peptide sequence. It is generated through the sequential cleavage of APP by enzymes called β-secretase and γ-secretase. In Alzheimer's disease, abnormal processing of APP leads to the accumulation and aggregation of Aβ peptides, leading to the formation of insoluble amyloid plaques in the brain.

Amyloid β-Peptide (1-42) is considered to be particularly relevant in Alzheimer's disease because it has a high propensity to aggregate and form toxic oligomers and fibrils. These aggregates are believed to play a crucial role in the neurodegenerative processes associated with the disease, including the formation of neurofibrillary tangles and neuronal damage.

Application

Here are some of its notable applications:

Disease Mechanism Studies: Amyloid β-Peptide (1-42) is extensively used in laboratory research to study the underlying mechanisms of Alzheimer's disease. Researchers investigate its role in the formation of amyloid plaques, aggregation processes, and the toxicity of amyloid β-peptides. This helps in understanding the pathology of the disease and identifying potential therapeutic targets.

Drug Development and Screening: Amyloid β-Peptide (1-42) serves as a valuable tool in the development and screening of potential drugs for Alzheimer's disease. Researchers utilize it to assess the efficacy of compounds that target amyloid β-peptide aggregation, clearance mechanisms, or related pathways. It aids in the identification and evaluation of novel drug candidates.

Biomarker Studies: As a key component of amyloid plaques in Alzheimer's disease, Amyloid β-Peptide (1-42) is investigated as a potential biomarker. Researchers explore its levels in cerebrospinal fluid (CSF) and blood samples to assess its diagnostic and prognostic value in identifying individuals at risk of developing Alzheimer's disease or monitoring disease progression.

Development of Therapeutic Strategies: Amyloid β-Peptide (1-42) research contributes to the development of therapeutic strategies aimed at preventing or reducing amyloid plaque formation and associated neurodegeneration. It helps in understanding the mechanisms through which amyloid β-peptides contribute to neuronal toxicity and guides the design of interventions to mitigate their effects.

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